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Genetron Health Helped Huashan Hospital Find the New Familial Pathogenic Gene of Pituitary Tumor

Release Time: 2018-01-12

With the support of China Pituitary Tumor Cooperative Team and Shanghai Pituitary Tumor Research Center and led by the pituitary tumor research team from Huashan Hospital Fudan University, which consists of professors Zhao Yao, Wang Yongfei, Li Shiqi, Li Yiming, Ye Hongying and Zhang Zhaoyun, in cooperation with Professor Shi Yongyong from Bio-X Research Institute of Shanghai Jiao Tong University, Professor Huang Chuanxin from Shanghai Institute of Immunology, Professor Yan Hai from Duke University and Beijing Genetron Health Technology Co., Ltd., a whole exome sequencing study had been conducted for a period of 3 years, covering 12 FPA pedigrees, 125 cases of sporadic pituitary tumors, and 260 cases of local persons as the normal control, by which it had been found for the first time that gene CDH23 is not only a kind of pathogenic gene of FPA but also a kind of susceptibility gene of sporadic pituitary tumor. Relevant research results had been published in the internationally well-known academic journal American Journal of Human Genetics (AJHG, Impact Factor 10.8) in May 2017.